The first thermodynamics in the world with regard to hemoglobin (2).

negative heteropic effector 

Due to that 2,3-BPG as a negative heteropic effector acts on (4)deoxyhemoglobinA more than (3)deoxyhemoglobinF,
(3)deoxyhemoglobinF has a greater affinity fou oxigen molecule than (4)deoxyhemoglobinA.
And that fact has historical significance.
On the other hand, in a simple explanation I try to make sure there are no logical fallacies without even mentioning its historical significance.
As a result, the logic described above became a very concise expression.
Subjectively, it is the first logical constitution in the world.
It's a seemingly innocent exression, but it's not always easy to figure it out.
After wondering whether to write the logic or not, I decided to write .